LIMAD

Identifying microbial proteins with amyloid potential and investigating their interactions with human Aβ42 and α-synuclein.

NCN · MINIATURA 9

Exploring the microbial side of amyloid diseases.

Identifying microbial proteins with amyloid potential and investigating their interactions with human Aβ42 and α-synuclein.

Microbiome · Amyloids · Structural biology

Programme: NCN · Miniatura 9
Grant ID: 2025/09/X/NZ7/00600
Start date: 21 Aug 2025
Duration: 12 months
Budget: PLN49,999.00

The research question

Microbial proteins may influence the aggregation of human amyloid-forming proteins. LIMAD focuses on the identification of microbial candidates and their possible cross-interactions with Aβ42 and α-synuclein, combining evidence review, sequence screening and computational investigation.

What the project sets out to do

01 / RESEARCH AIM

Find candidate proteins

Review microbes associated with Alzheimer’s and Parkinson’s diseases and screen their proteins for amyloid potential.

02 / RESEARCH AIM

Investigate cross-interactions

Combine machine learning and structural biology to investigate interactions with Aβ42 and α-synuclein.

03 / RESEARCH AIM

Develop testable hypotheses

Identify microbial contributions to aggregation and prioritise candidates for future studies of possible targets and prevention strategies.

People & support

Project lead: Valentín Iglesias.

National Science Center Poland

Full project title
LIMAD: Large-scale identification of microorganism products impacting amyloid diseases